C++ TreeTemplate类代码示例

string Alignment::get_abayes_tree() {
    TreeTemplate<Node> tree = TreeTemplate<Node>(likelihood->getTree());
    std::map<int, nniIDs> nniMap;

    for (auto& node : tree.getNodes()) {
        if (node->hasFather() && node->getFather()->hasFather()) {
            auto search = nniMap.find(node->getFatherId());
            if (search == nniMap.end()) {
                nniMap[node->getFatherId()].rearr1 = node->getId();
            }
            else {
                search->second.rearr2 = node->getId();
            };
        }
    }

    for (auto entry : nniMap) {
        double lnl1 = -likelihood->testNNI(entry.second.rearr1);
        double lnl2 = -likelihood->testNNI(entry.second.rearr2);
        bpp::Number<double> abayes = 1 / (1 + exp(lnl1) + exp(lnl2));
        tree.setBranchProperty(entry.first, TreeTools::BOOTSTRAP, abayes);
    }

    string s = TreeTools::treeToParenthesis(tree, true, TreeTools::BOOTSTRAP);
    s.erase(s.find_last_not_of(" \n\r\t")+1);
    return s;
}

int main() {
  TreeTemplate<Node>* tree = TreeTemplateTools::parenthesisToTree("((A:0.001, B:0.002):0.003,C:0.01,D:0.1);");
  cout << tree->getNumberOfLeaves() << endl;
  vector<int> ids = tree->getNodesId();
  //-------------

  NucleicAlphabet* alphabet = new DNA();
  SubstitutionModel* model = new GTR(alphabet, 1, 0.2, 0.3, 0.4, 0.4, 0.1, 0.35, 0.35, 0.2);
  //DiscreteDistribution* rdist = new GammaDiscreteDistribution(4, 0.4, 0.4);
  DiscreteDistribution* rdist = new ConstantDistribution(1.0);
  HomogeneousSequenceSimulator simulator(model, rdist, tree);

  unsigned int n = 100000;
  map<int, RowMatrix<unsigned int> > counts;
  for (size_t j = 0; j < ids.size() - 1; ++j) //ignore root, the last id
    counts[ids[j]].resize(4, 4);
  for (unsigned int i = 0; i < n; ++i) {
    RASiteSimulationResult* result = simulator.dSimulate();
    for (size_t j = 0; j < ids.size() - 1; ++j) { //ignore root, the last id
      result->getMutationPath(ids[j]).getEventCounts(counts[ids[j]]);
    }
    delete result;
  }
  map<int, RowMatrix<double> >freqs;
  map<int, double> sums;
  for (size_t k = 0; k < ids.size() - 1; ++k) { //ignore root, the last id
    RowMatrix<double>* freqsP = &freqs[ids[k]];
    RowMatrix<unsigned int>* countsP = &counts[ids[k]];
    freqsP->resize(4, 4);
    for (unsigned int i = 0; i < 4; ++i)
      for (unsigned int j = 0; j < 4; ++j)
        (*freqsP)(i, j) = static_cast<double>((*countsP)(i, j)) / (static_cast<double>(n));
    
    //For now we simply compare the total number of substitutions:
    sums[ids[k]] = MatrixTools::sumElements(*freqsP);
  
    cout << "Br" << ids[k] << " BrLen = " << tree->getDistanceToFather(ids[k]) << " counts = " << sums[ids[k]] << endl;
    MatrixTools::print(*freqsP);
  }
  //We should compare this matrix with the expected one!

  for (size_t k = 0; k < ids.size() - 1; ++k) { //ignore root, the last id
    if (abs(sums[ids[k]] - tree->getDistanceToFather(ids[k])) > 0.01) {
      delete tree;
      delete alphabet;
      delete model;
      delete rdist;
      return 1;
    }
  }
  //-------------
  delete tree;
  delete alphabet;
  delete model;
  delete rdist;

  //return (abs(obs - 0.001) < 0.001 ? 0 : 1);
  return 0;
}

string TreeTemplateTools::treeToParenthesis(const TreeTemplate<Node>& tree, bool writeId)
{
  ostringstream s;
  s << "(";
  const Node* node = tree.getRootNode();
  if (node->hasNoSon())
  {
    s << node->getName();
    for (size_t i = 0; i < node->getNumberOfSons(); ++i)
    {
      s << "," << nodeToParenthesis(*node->getSon(i), writeId);
    }
  }
  else
  {
    s << nodeToParenthesis(*node->getSon(0), writeId);
    for (size_t i = 1; i < node->getNumberOfSons(); ++i)
    {
      s << "," << nodeToParenthesis(*node->getSon(i), writeId);
    }
  }
  s << ")";
  if (node->hasDistanceToFather())
    s << ":" << node->getDistanceToFather();
  s << ";" << endl;
  return s.str();
}

double TreeTemplateTools::getRadius(TreeTemplate<Node>& tree)
{
  TreeTemplateTools::midRoot(tree, MIDROOT_SUM_OF_SQUARES, false);
  Moments_ moments = getSubtreeMoments_(tree.getRootNode());
  double radius = moments.sum / moments.numberOfLeaves;
  return radius;
}

TreeTemplate<Node>* TreeTemplateTools::parenthesisToTree(const string& description, bool bootstrap, const string& propertyName, bool withId, bool verbose) throw (Exception)
{
  string::size_type semi = description.rfind(';');
  if (semi == string::npos)
    throw Exception("TreeTemplateTools::parenthesisToTree(). Bad format: no semi-colon found.");
  string content = description.substr(0, semi);
  unsigned int nodeCounter = 0;
  Node* node = parenthesisToNode(content, nodeCounter, bootstrap, propertyName, withId, verbose);
  TreeTemplate<Node>* tree = new TreeTemplate<Node>();
  tree->setRootNode(node);
  if (!withId)
  {
    tree->resetNodesId();
  }
  if (verbose) {
    (*ApplicationTools::message) << " nodes loaded.";
    ApplicationTools::message->endLine();
  }
  return tree;
}

RecursiveLikelihoodTree::RecursiveLikelihoodTree(const SubstitutionProcess& process, bool usepatterns) :
  AbstractLikelihoodTree(process),
  vTree_(),
  patternLinks_(),
  usePatterns_(usepatterns),
  initializedAboveLikelihoods_(false)
{
  TreeTemplate<Node> tree = process.getParametrizableTree().getTree();

  RecursiveLikelihoodNode* rCN = TreeTemplateTools::cloneSubtree<RecursiveLikelihoodNode>(*tree.getRootNode());

  TreeTemplate<RecursiveLikelihoodNode>* pTC = new TreeTemplate<RecursiveLikelihoodNode>(rCN);

  for (size_t i = 0; i < nbClasses_; i++)
  {
    TreeTemplate<RecursiveLikelihoodNode>* pTC2 = pTC->clone();
    vTree_.push_back(pTC2);
  }

  delete pTC;
}

Tree::Tree( const TreeTemplate& tmpl ) :
mPosition( 0.0, 0.0, 0.0 ),
mAngle( 0.0, 0.0, 0.0 ),
mScale( 1.0, 1.0, 1.0 ),
mNodes( 0 ),
mNodeNumber( 0 ),
mTime( 0.0 ){
	mNodeNumber = tmpl.nodeNumber();
	mNodes = new Node[ mNodeNumber ];
	for ( int i = 0; i < mNodeNumber; ++i ){
		Node& dst = mNodes[ i ];
		const NodeTemplate* src = tmpl.node( i );
		//パラメータを移す
		dst.setTranslation( *src->translation() );
		dst.setRotation( *src->rotation() );
		dst.setScale( *src->scale() );
		dst.setName( src->name()->c_str() );
		dst.setBatch( src->batch() );

		//[長男-兄弟形式から子配列形式への変換]
		//子の数を数える
		int child = src->child();
		int childNumber = 0;
		while ( child >= 0 ){
			++childNumber;
			child = tmpl.node( child )->brother();
		}
		//子をアロケート
		dst.setChildNumber( childNumber );
		//子を充填する
		child = src->child();
		int j = 0;
		while ( child >= 0 ){
			dst.setChild( j, mNodes + child );
			child = tmpl.node( child )->brother();
			++j;
		}
	}
}

TreeTemplate<Node>* TreeTemplateTools::getRandomTree(vector<string>& leavesNames, bool rooted)
{
  if (leavesNames.size() == 0)
    return 0;                                // No taxa.
  // This vector will contain all nodes.
  // Start with all leaves, and then group nodes randomly 2 by 2.
  // Att the end, contains only the root node of the tree.
  vector<Node*> nodes(leavesNames.size());
  // Create all leaves nodes:
  for (size_t i = 0; i < leavesNames.size(); ++i)
  {
    nodes[i] = new Node(leavesNames[i]);
  }
  // Now group all nodes:
  while (nodes.size() > (rooted ? 2 : 3))
  {
    // Select random nodes:
    size_t pos1 = RandomTools::giveIntRandomNumberBetweenZeroAndEntry<size_t>(nodes.size());
    Node* node1 = nodes[pos1];
    nodes.erase(nodes.begin() + static_cast<ptrdiff_t>(pos1));
    size_t pos2 = RandomTools::giveIntRandomNumberBetweenZeroAndEntry<size_t>(nodes.size());
    Node* node2 = nodes[pos2];
    nodes.erase(nodes.begin() + static_cast<ptrdiff_t>(pos2));
    // Add new node:
    Node* parent = new Node();
    parent->addSon(node1);
    parent->addSon(node2);
    nodes.push_back(parent);
  }
  // Return tree with last node as root node:
  Node* root = new Node();
  for (size_t i = 0; i < nodes.size(); ++i)
  {
    root->addSon(nodes[i]);
  }
  TreeTemplate<Node>* tree = new TreeTemplate<Node>(root);
  tree->resetNodesId();
  return tree;
}

int main() {
  TreeTemplate<Node>* tree = TreeTemplateTools::parenthesisToTree("(((A:0.01, B:0.01):0.02,C:0.03):0.01,D:0.04);");
  vector<string> seqNames = tree->getLeavesNames();
  vector<int> ids = tree->getNodesId();
  //-------------

  const NucleicAlphabet* alphabet = &AlphabetTools::DNA_ALPHABET;
  SubstitutionModel* model = new T92(alphabet, 3.);
  DiscreteDistribution* rdist = new GammaDiscreteDistribution(4, 1.0);
  rdist->aliasParameters("alpha", "beta");

  VectorSiteContainer sites(alphabet);
  sites.addSequence(BasicSequence("A", "AAATGGCTGTGCACGTC", alphabet));
  sites.addSequence(BasicSequence("B", "AACTGGATCTGCATGTC", alphabet));
  sites.addSequence(BasicSequence("C", "ATCTGGACGTGCACGTG", alphabet));
  sites.addSequence(BasicSequence("D", "CAACGGGAGTGCGCCTA", alphabet));

  try {
    fitModelH(model, rdist, *tree, sites, 93.017264552603336369, 71.265543199977557265);
  } catch (Exception& ex) {
    cerr << ex.what() << endl;
    return 1;
  }
  try {
    fitModelHClock(model, rdist, *tree, sites, 92.27912072473920090943, 71.26554020984087856050);
  } catch (Exception& ex) {
    cerr << ex.what() << endl;
    return 1;
  }

  //-------------
  delete tree;
  delete model;
  delete rdist;

  return 0;
}

string TreeTemplateTools::treeToParenthesis(const TreeTemplate<Node>& tree, bool bootstrap, const string& propertyName)
{
  ostringstream s;
  s << "(";
  const Node* node = tree.getRootNode();
  if (node->hasNoSon())
  {
    s << node->getName();
    for (size_t i = 0; i < node->getNumberOfSons(); i++)
    {
      s << "," << nodeToParenthesis(*node->getSon(i), bootstrap, propertyName);
    }
  }
  else
  {
    s << nodeToParenthesis(*node->getSon(0), bootstrap, propertyName);
    for (size_t i = 1; i < node->getNumberOfSons(); i++)
    {
      s << "," << nodeToParenthesis(*node->getSon(i), bootstrap, propertyName);
    }
  }
  s << ")";
  if (bootstrap)
  {
    if (node->hasBranchProperty(TreeTools::BOOTSTRAP))
      s << (dynamic_cast<const Number<double>*>(node->getBranchProperty(TreeTools::BOOTSTRAP))->getValue());
  }
  else
  {
    if (node->hasBranchProperty(propertyName))
    {
      const BppString* ppt = dynamic_cast<const BppString*>(node->getBranchProperty(propertyName));
      if (ppt)
        s << *ppt;
      else
        throw Exception("TreeTemplateTools::nodeToParenthesis. Property should be a BppString.");
    }
  }
  s << ";" << endl;
  return s.str();
}

void NexusIOTree::read(std::istream& in, std::vector<Tree*>& trees) const throw (Exception)
{
	// Checking the existence of specified file
	if (! in) { throw IOException ("NexusIOTree::read(). Failed to read from stream"); }
	
  //Look for the TREES block:
  string line = "";
  while (TextTools::toUpper(line) != "BEGIN TREES;")
  {
    if (in.eof())
      throw Exception("NexusIOTree::read(). No trees block was found.");
    line = TextTools::removeSurroundingWhiteSpaces(FileTools::getNextLine(in));
  }
  
  string cmdName = "", cmdArgs = "";
  bool cmdFound = NexusTools::getNextCommand(in, cmdName, cmdArgs, false);
  if (! cmdFound)
    throw Exception("NexusIOTree::read(). Missing tree command.");
  cmdName = TextTools::toUpper(cmdName);

  //Look for the TRANSLATE command:
  map<string, string> translation;
  bool hasTranslation = false;
  if (cmdName == "TRANSLATE")
  {
    //Parse translation:
    StringTokenizer st(cmdArgs, ",");
    while (st.hasMoreToken())
    {
      string tok = TextTools::removeSurroundingWhiteSpaces(st.nextToken());
      NestedStringTokenizer nst(tok, "'", "'", " \t");
      if (nst.numberOfRemainingTokens() != 2)
        throw Exception("NexusIOTree::read(). Unvalid translation description.");
      string name = nst.nextToken();
      string tln  = nst.nextToken();
      translation[name] = tln;
    }
    hasTranslation = true;
    cmdFound = NexusTools::getNextCommand(in, cmdName, cmdArgs, false);
    if (! cmdFound)
      throw Exception("NexusIOTree::read(). Missing tree command.");
    else
      cmdName = TextTools::toUpper(cmdName);
  }

  //Now parse the trees:
  while (cmdFound && cmdName != "END")
  {
    if (cmdName != "TREE")
      throw Exception("NexusIOTree::read(). Unvalid command found: " + cmdName);
    string::size_type pos = cmdArgs.find("=");
    if (pos == string::npos)
      throw Exception("NexusIOTree::read(). unvalid format, should be tree-name=tree-description");
    string description = cmdArgs.substr(pos + 1);
	  TreeTemplate<Node>* tree = TreeTemplateTools::parenthesisToTree(description + ";", true);

    //Now translate leaf names if there is a translation:
    //(we assume that all trees share the same translation! ===> check!)
    if (hasTranslation)
    {
      vector<Node*> leaves = tree->getLeaves();
      for (size_t i = 0; i < leaves.size(); i++)
      {
        string name = leaves[i]->getName();
        if (translation.find(name) == translation.end())
        {
          throw Exception("NexusIOTree::read(). No translation was given for this leaf: " + name);
        }
        leaves[i]->setName(translation[name]);
      }
    }
    trees.push_back(tree);
    cmdFound = NexusTools::getNextCommand(in, cmdName, cmdArgs, false);
    if (cmdFound) cmdName = TextTools::toUpper(cmdName);
  }
}

void TreeTemplateTools::midRoot(TreeTemplate<Node>& tree, short criterion, bool forceBranchRoot)
{
  if (criterion != MIDROOT_VARIANCE && criterion != MIDROOT_SUM_OF_SQUARES)
    throw Exception("TreeTemplateTools::midRoot(). Illegal criterion value '" + TextTools::toString(criterion) + "'");

  if (tree.isRooted())
    tree.unroot();
  Node* ref_root = tree.getRootNode();
  //
  // The bestRoot object records :
  // -- the current best branch : .first
  // -- the current best value of the criterion : .second["value"]
  // -- the best position of the root on the branch : .second["position"]
  //      0 is toward the original root, 1 is away from it
  //
  pair<Node*, map<string, double> > best_root_branch;
  best_root_branch.first = ref_root; // nota: the root does not correspond to a branch as it has no father
  best_root_branch.second ["position"] = -1;
  best_root_branch.second ["score"] = numeric_limits<double>::max();

  // find the best root
  getBestRootInSubtree_(tree, criterion, ref_root, best_root_branch);
  tree.rootAt(ref_root); // back to the original root

  // reroot
  const double pos = best_root_branch.second["position"];
  if (pos < 1e-6 or pos > 1 - 1e-6)
    // The best root position is on a node (this is often the case with the sum of squares criterion)
    tree.rootAt(pos < 1e-6 ? best_root_branch.first->getFather() : best_root_branch.first);
  else
  // The best root position is somewhere on a branch (a new Node is created)
  {
    Node* new_root = new Node();
    new_root->setId( TreeTools::getMPNUId(tree, tree.getRootId()) );

    double root_branch_length = best_root_branch.first->getDistanceToFather();
    Node* best_root_father = best_root_branch.first->getFather();

    best_root_father->removeSon(best_root_branch.first);
    best_root_father->addSon(new_root);
    new_root->addSon(best_root_branch.first);

    new_root->setDistanceToFather(max(pos * root_branch_length, 1e-6));
    best_root_branch.first->setDistanceToFather(max((1 - pos) * root_branch_length, 1e-6));

    // The two branches leaving the root must have the same branch properties
    const vector<string> branch_properties = best_root_branch.first->getBranchPropertyNames();
    for (vector<string>::const_iterator p = branch_properties.begin(); p != branch_properties.end(); ++p)
    {
      new_root->setBranchProperty(*p, *best_root_branch.first->getBranchProperty(*p));
    }

    tree.rootAt(new_root);
  }

  if (forceBranchRoot) // if we want the root to be on a branch, not on a node
  {
    Node* orig_root = tree.getRootNode();
    vector<Node*> root_sons = orig_root->getSons();
    if (root_sons.size() > 2)
    {
      Node* nearest = root_sons.at(0);
      for (vector<Node*>::iterator n = root_sons.begin(); n !=
           root_sons.end(); ++n)
      {
        if ((**n).getDistanceToFather() < nearest->getDistanceToFather())
          nearest = *n;
      }
      const double d = nearest->getDistanceToFather();
      Node* new_root = new Node();
      new_root->setId( TreeTools::getMPNUId(tree, tree.getRootId()) );
      orig_root->removeSon(nearest);
      orig_root->addSon(new_root);
      new_root->addSon(nearest);
      new_root->setDistanceToFather(d / 2.);
      nearest->setDistanceToFather(d / 2.);
      const vector<string> branch_properties = nearest->getBranchPropertyNames();
      for (vector<string>::const_iterator p = branch_properties.begin(); p != branch_properties.end(); ++p)
      {
        new_root->setBranchProperty(*p, *nearest->getBranchProperty(*p));
      }
      tree.rootAt(new_root);
    }
  }
}

int main() {

  TreeTemplate<Node>* tree = TreeTemplateTools::parenthesisToTree("(((A:0.1, B:0.2):0.3,C:0.1):0.2,(D:0.3,(E:0.2,F:0.05):0.1):0.1);");

  vector<string> seqNames= tree->getLeavesNames();
  vector<int> ids = tree->getNodesId();
  //-------------

  const NucleicAlphabet* alphabet = &AlphabetTools::DNA_ALPHABET;
  FrequenciesSet* rootFreqs = new GCFrequenciesSet(alphabet);
  
  SubstitutionModel* model = new T92(alphabet, 3.);
  std::vector<std::string> globalParameterNames;
  globalParameterNames.push_back("T92.kappa");

  //Very difficult to optimize on small datasets:
  DiscreteDistribution* rdist = new GammaDiscreteRateDistribution(4, 1.0);
  
  ParametrizableTree* parTree = new ParametrizableTree(*tree);
  FrequenciesSet* rootFreqs2 = rootFreqs->clone();
  DiscreteDistribution* rdist2 = rdist->clone();
  SubstitutionModel* model2=model->clone();

  map<string, string> alias;

  SubstitutionModelSet* modelSet = SubstitutionModelSetTools::createNonHomogeneousModelSet(model, rootFreqs, tree, alias, globalParameterNames);
  unique_ptr<SubstitutionModelSet> modelSetSim(modelSet->clone());

  NonHomogeneousSubstitutionProcess* subPro= NonHomogeneousSubstitutionProcess::createNonHomogeneousSubstitutionProcess(model2, rdist2, rootFreqs2, parTree, globalParameterNames);

  // Simulation
    
  size_t nsites = 1000;
  unsigned int nrep = 20;
  size_t nmodels = modelSet->getNumberOfModels();
  vector<double> thetas(nmodels);
  vector<double> thetasEst1(nmodels);
  vector<double> thetasEst2(nmodels);
  vector<double> thetasEst1n(nmodels);
  vector<double> thetasEst2n(nmodels);

  for (size_t i = 0; i < nmodels; ++i) {
    double theta = RandomTools::giveRandomNumberBetweenZeroAndEntry(0.99) + 0.005;
    cout << "Theta" << i << " set to " << theta << endl; 
    modelSetSim->setParameterValue("T92.theta_" + TextTools::toString(i + 1), theta);
    //subPro->setParameterValue("T92.theta_" + TextTools::toString(i + 1), theta);
    thetas[i] = theta;
  }

  NonHomogeneousSequenceSimulator simulator(modelSetSim.get(), rdist, tree);

  NonHomogeneousSubstitutionProcess* subPro2 = subPro->clone();

  for (unsigned int j = 0; j < nrep; j++) {

    OutputStream* profiler  = new StlOutputStream(new ofstream("profile.txt", ios::out));
    OutputStream* messenger = new StlOutputStream(new ofstream("messages.txt", ios::out));

    //Simulate data:
    unique_ptr<SiteContainer> sites(simulator.simulate(nsites));

    //Now fit model:
    unique_ptr<SubstitutionModelSet> modelSet2(modelSet->clone());

    RNonHomogeneousTreeLikelihood tl(*tree, *sites.get(), modelSet, rdist, true, true, false);
    tl.initialize();

    RNonHomogeneousTreeLikelihood tl2(*tree, *sites.get(), modelSet2.get(), rdist, true, true, true);
    tl2.initialize();

    SubstitutionProcess* nsubPro=subPro->clone();
    SubstitutionProcess* nsubPro2=subPro2->clone();
    
    RecursiveLikelihoodTreeCalculation* tlComp = new RecursiveLikelihoodTreeCalculation(*sites->clone(), nsubPro, true, false);
    SingleProcessPhyloLikelihood ntl(nsubPro, tlComp, true);

    RecursiveLikelihoodTreeCalculation* tlComp2 = new RecursiveLikelihoodTreeCalculation(*sites->clone(), nsubPro2, true);
    SingleProcessPhyloLikelihood ntl2(nsubPro2, tlComp2, true);

    for (size_t i = 0; i < nmodels; ++i) {
      ntl.setParameterValue("T92.theta_" + TextTools::toString(i + 1), thetas[i]);
      ntl2.setParameterValue("T92.theta_" + TextTools::toString(i + 1), thetas[i]);
    }

    cout << setprecision(10) << "OldTL init: "  << tl.getValue() << "\t" << tl2.getValue() << endl;
    cout << setprecision(10) << "NewTL init: "  << ntl.getValue() << "\t" << ntl2.getValue() << endl;

    unsigned int c1 = OptimizationTools::optimizeNumericalParameters2(
      &tl, tl.getParameters(), 0,
      0.0001, 10000, messenger, profiler, false, false, 1, OptimizationTools::OPTIMIZATION_NEWTON);
    
    
    unsigned int c2 = OptimizationTools::optimizeNumericalParameters2(
      &tl2, tl2.getParameters(), 0,
      0.0001, 10000, messenger, profiler, false, false, 1, OptimizationTools::OPTIMIZATION_NEWTON);

    unsigned int nc1 = OptimizationTools::optimizeNumericalParameters2(
      &ntl, ntl.getParameters(), 0,
      0.0001, 10000, messenger, profiler, false, false, 1, OptimizationTools::OPTIMIZATION_NEWTON);

//.........这里部分代码省略.........

int main() {
  TreeTemplate<Node>* tree = TreeTemplateTools::parenthesisToTree("((A:0.001, B:0.002):0.008,C:0.01,D:0.1);");
  vector<int> ids = tree->getNodesId();
  ids.pop_back(); //Ignore root

  //-------------

  CodonAlphabet* alphabet = new CodonAlphabet(&AlphabetTools::DNA_ALPHABET);
  GeneticCode* gc = new StandardGeneticCode(&AlphabetTools::DNA_ALPHABET);
  CodonSubstitutionModel* model = new YN98(gc, CodonFrequenciesSet::getFrequenciesSetForCodons(CodonFrequenciesSet::F0, gc));
  //SubstitutionModel* model = new CodonRateSubstitutionModel(
  //      gc,
  //      new JCnuc(dynamic_cast<CodonAlphabet*>(alphabet)->getNucleicAlphabet()));
  cout << model->getNumberOfStates() << endl;
  MatrixTools::printForR(model->getGenerator(), "g");
  DiscreteDistribution* rdist = new ConstantDistribution(1.0);
  HomogeneousSequenceSimulator simulator(model, rdist, tree);
  TotalSubstitutionRegister* totReg = new TotalSubstitutionRegister(model);
  DnDsSubstitutionRegister* dndsReg = new DnDsSubstitutionRegister(model);

  unsigned int n = 20000;
  vector< vector<double> > realMap(n);
  vector< vector< vector<double> > > realMapTotal(n);
  vector< vector< vector<double> > > realMapDnDs(n);
  VectorSiteContainer sites(tree->getLeavesNames(), alphabet);
  for (unsigned int i = 0; i < n; ++i) {
    ApplicationTools::displayGauge(i, n-1, '=');
    RASiteSimulationResult* result = simulator.dSimulateSite();
    realMap[i].resize(ids.size());
    realMapTotal[i].resize(ids.size());
    realMapDnDs[i].resize(ids.size());
    for (size_t j = 0; j < ids.size(); ++j) {
      realMap[i][j] = static_cast<double>(result->getSubstitutionCount(ids[j]));
      realMapTotal[i][j].resize(totReg->getNumberOfSubstitutionTypes());
      realMapDnDs[i][j].resize(dndsReg->getNumberOfSubstitutionTypes());
      result->getSubstitutionCount(ids[j], *totReg, realMapTotal[i][j]);
      result->getSubstitutionCount(ids[j], *dndsReg, realMapDnDs[i][j]);
      if (realMapTotal[i][j][0] != realMap[i][j]) {
        cerr << "Error, total substitution register provides wrong result." << endl;
        return 1;
      }
      //if (abs(VectorTools::sum(realMapDetailed[i][j]) - realMap[i][j]) > 0.000001) {
      //  cerr << "Error, detailed substitution register provides wrong result." << endl;
      //  return 1;
      //}
    }
    auto_ptr<Site> site(result->getSite(*model));
    site->setPosition(static_cast<int>(i));
    sites.addSite(*site, false);
    delete result;
  }
  ApplicationTools::displayTaskDone();
  
  //-------------
  //Now build the substitution vectors with the true model:
  //Fasta fasta;
  //fasta.write("Simulations.fasta", sites);
  DRHomogeneousTreeLikelihood drhtl(*tree, sites, model, rdist);
  drhtl.initialize();
  cout << drhtl.getValue() << endl;
 
  SubstitutionCount* sCountAna = new LaplaceSubstitutionCount(model, 10);
  Matrix<double>* m = sCountAna->getAllNumbersOfSubstitutions(0.001,1);
  cout << "Analytical total count:" << endl;
  MatrixTools::print(*m);
  delete m;
  ProbabilisticSubstitutionMapping* probMapAna = 
    SubstitutionMappingTools::computeSubstitutionVectors(drhtl, ids, *sCountAna);

  SubstitutionCount* sCountTot = new NaiveSubstitutionCount(model, totReg);
  m = sCountTot->getAllNumbersOfSubstitutions(0.001,1);
  cout << "Simple total count:" << endl;
  MatrixTools::print(*m);
  delete m;
  ProbabilisticSubstitutionMapping* probMapTot = 
    SubstitutionMappingTools::computeSubstitutionVectors(drhtl, ids, *sCountTot);

  SubstitutionCount* sCountDnDs = new NaiveSubstitutionCount(model, dndsReg);
  m = sCountDnDs->getAllNumbersOfSubstitutions(0.001,1);
  cout << "Detailed count, type 1:" << endl;
  MatrixTools::print(*m);
  delete m;
  ProbabilisticSubstitutionMapping* probMapDnDs = 
    SubstitutionMappingTools::computeSubstitutionVectors(drhtl, ids, *sCountDnDs);

  SubstitutionCount* sCountUniTot = new UniformizationSubstitutionCount(model, totReg);
  m = sCountUniTot->getAllNumbersOfSubstitutions(0.001,1);
  cout << "Total count, uniformization method:" << endl;
  MatrixTools::print(*m);
  delete m;
  ProbabilisticSubstitutionMapping* probMapUniTot = 
    SubstitutionMappingTools::computeSubstitutionVectors(drhtl, ids, *sCountUniTot);

  SubstitutionCount* sCountUniDnDs = new UniformizationSubstitutionCount(model, dndsReg);
  m = sCountUniDnDs->getAllNumbersOfSubstitutions(0.001,2);
  cout << "Detailed count, uniformization method, type 2:" << endl;
  MatrixTools::print(*m);
  delete m;
  ProbabilisticSubstitutionMapping* probMapUniDnDs = 
    SubstitutionMappingTools::computeSubstitutionVectors(drhtl, ids, *sCountUniDnDs);
//.........这里部分代码省略.........

void TreeTemplateTools::getBestRootInSubtree_(TreeTemplate<Node>& tree, short criterion, Node* node, pair<Node*, map<string, double> >& bestRoot)
{
  const vector<Node*> sons = node->getSons(); // copy
  tree.rootAt(node);

  // Try to place the root on each branch downward node
  for (vector<Node*>::const_iterator son = sons.begin(); son != sons.end(); ++son)
  {
    // Compute the moment of the subtree on son's side
    Moments_ son_moment = getSubtreeMoments_(*son);

    // Compute the moment of the subtree on node's side
    tree.rootAt(*son);
    Moments_ node_moment = getSubtreeMoments_(node);
    tree.rootAt(node);

    /*
     * Get the position of the root on this branch that
     * minimizes the root-to-leaves distances variance.
     *
     * This variance can be written in the form A x^2 + B x + C
     */
    double min_criterion_value;
    double best_position; // 0 is toward the root, 1 is away from it

    const TreeTemplateTools::Moments_& m1 = node_moment;
    const TreeTemplateTools::Moments_& m2 = son_moment;
    const double d = (**son).getDistanceToFather();
    const double n1 = m1.numberOfLeaves;
    const double n2 = m2.numberOfLeaves;

    double A = 0, B = 0, C = 0;
    if (criterion == MIDROOT_SUM_OF_SQUARES)
    {
      A = (n1 + n2) * d * d;
      B = 2 * d * (m1.sum - m2.sum) - 2 * n2 * d * d;
      C = m1.squaresSum + m2.squaresSum
          + 2 * m2.sum * d
          + n2 * d * d;
    }
    else if (criterion == MIDROOT_VARIANCE)
    {
      A = 4 * n1 * n2 * d * d;
      B = 4 * d * ( n2 * m1.sum - n1 * m2.sum - d * n1 * n2);
      C = (n1 + n2) * (m1.squaresSum + m2.squaresSum) + n1 * d * n2 * d
          + 2 * n1 * d * m2.sum - 2 * n2 * d * m1.sum
          - (m1.sum + m2.sum) * (m1.sum + m2.sum);
    }

    if (A < 1e-20)
    {
      min_criterion_value = numeric_limits<double>::max();
      best_position = 0.5;
    }
    else
    {
      min_criterion_value = C - B * B / (4 * A);
      best_position = -B / (2 * A);
      if (best_position < 0)
      {
        best_position = 0;
        min_criterion_value = C;
      }
      else if (best_position > 1)
      {
        best_position = 1;
        min_criterion_value = A + B + C;
      }
    }

    // Is this branch is the best seen, update 'bestRoot'
    if (min_criterion_value < bestRoot.second["score"])
    {
      bestRoot.first = *son;
      bestRoot.second["position"] = best_position;
      bestRoot.second["score"] = min_criterion_value;
    }

    // Recurse
    TreeTemplateTools::getBestRootInSubtree_(tree, criterion, *son, bestRoot);
  }
}