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Java Genotype.getExtendedAttributes方法代码示例

本文整理汇总了Java中htsjdk.variant.variantcontext.Genotype.getExtendedAttributes方法的典型用法代码示例。如果您正苦于以下问题:Java Genotype.getExtendedAttributes方法的具体用法?Java Genotype.getExtendedAttributes怎么用?Java Genotype.getExtendedAttributes使用的例子?那么, 这里精选的方法代码示例或许可以为您提供帮助。您也可以进一步了解该方法所在htsjdk.variant.variantcontext.Genotype的用法示例。


在下文中一共展示了Genotype.getExtendedAttributes方法的2个代码示例,这些例子默认根据受欢迎程度排序。您可以为喜欢或者感觉有用的代码点赞,您的评价将有助于系统推荐出更棒的Java代码示例。

示例1: cleanupGenotypeAnnotations

import htsjdk.variant.variantcontext.Genotype; //导入方法依赖的package包/类
/**
 * Cleans up genotype-level annotations that need to be updated.
 * 1. move MIN_DP to DP if present
 * 2. propagate DP to AD if not present
 * 3. remove SB if present
 * 4. change the PGT value from "0|1" to "1|1" for homozygous variant genotypes
 *
 * @param VC            the VariantContext with the Genotypes to fix
 * @param createRefGTs  if true we will also create proper hom ref genotypes since we assume the site is monomorphic
 * @return a new set of Genotypes
 */
private List<Genotype> cleanupGenotypeAnnotations(final VariantContext VC, final boolean createRefGTs) {
    final GenotypesContext oldGTs = VC.getGenotypes();
    final List<Genotype> recoveredGs = new ArrayList<>(oldGTs.size());
    for ( final Genotype oldGT : oldGTs ) {
        final Map<String, Object> attrs = new HashMap<>(oldGT.getExtendedAttributes());

        final GenotypeBuilder builder = new GenotypeBuilder(oldGT);
        int depth = oldGT.hasDP() ? oldGT.getDP() : 0;

        // move the MIN_DP to DP
        if ( oldGT.hasExtendedAttribute("MIN_DP") ) {
            depth = Integer.parseInt((String)oldGT.getAnyAttribute("MIN_DP"));
            builder.DP(depth);
            attrs.remove("MIN_DP");
        }

        // remove SB
        attrs.remove("SB");

        // update PGT for hom vars
        if ( oldGT.isHomVar() && oldGT.hasExtendedAttribute(HaplotypeCaller.HAPLOTYPE_CALLER_PHASING_GT_KEY) ) {
            attrs.put(HaplotypeCaller.HAPLOTYPE_CALLER_PHASING_GT_KEY, "1|1");
        }

        // create AD if it's not there
        if ( !oldGT.hasAD() && VC.isVariant() ) {
            final int[] AD = new int[VC.getNAlleles()];
            AD[0] = depth;
            builder.AD(AD);
        }

        if ( createRefGTs ) {
            final int ploidy = oldGT.getPloidy();
            final List<Allele> refAlleles = Collections.nCopies(ploidy,VC.getReference());

            //keep 0 depth samples as no-call
            if (depth > 0) {
                builder.alleles(refAlleles);
            }

            // also, the PLs are technically no longer usable
            builder.noPL();
        }

        recoveredGs.add(builder.noAttributes().attributes(attrs).make());
    }
    return recoveredGs;
}
 
开发者ID:PAA-NCIC,项目名称:SparkSeq,代码行数:60,代码来源:GenotypeGVCFs.java

示例2: cleanupGenotypeAnnotations

import htsjdk.variant.variantcontext.Genotype; //导入方法依赖的package包/类
private List<Genotype> cleanupGenotypeAnnotations(final VariantContext VC, final boolean createRefGTs) {
	final GenotypesContext oldGTs = VC.getGenotypes();
	final List<Genotype> recoveredGs = new ArrayList<>(oldGTs.size());
	for (final Genotype oldGT : oldGTs) {
		final Map<String, Object> attrs = new HashMap<>(oldGT.getExtendedAttributes());

		final GenotypeBuilder builder = new GenotypeBuilder(oldGT);
		int depth = oldGT.hasDP() ? oldGT.getDP() : 0;

		// move the MIN_DP to DP
		if (oldGT.hasExtendedAttribute(GaeaVCFConstants.MIN_DP_FORMAT_KEY)) {
			depth = Integer.parseInt((String) oldGT.getAnyAttribute(GaeaVCFConstants.MIN_DP_FORMAT_KEY));
			builder.DP(depth);
			attrs.remove(GaeaVCFConstants.MIN_DP_FORMAT_KEY);
		}

		// move the GQ to RGQ
		if (createRefGTs && oldGT.hasGQ()) {
			builder.noGQ();
			attrs.put(GaeaVCFConstants.REFERENCE_GENOTYPE_QUALITY, oldGT.getGQ());
		}

		// remove SB
		attrs.remove(GaeaVCFConstants.STRAND_BIAS_BY_SAMPLE_KEY);

		// update PGT for hom vars
		if (oldGT.isHomVar() && oldGT.hasExtendedAttribute(GaeaVCFConstants.HAPLOTYPE_CALLER_PHASING_GT_KEY)) {
			attrs.put(GaeaVCFConstants.HAPLOTYPE_CALLER_PHASING_GT_KEY, "1|1");
		}

		// create AD if it's not there
		if (!oldGT.hasAD() && VC.isVariant()) {
			final int[] AD = new int[VC.getNAlleles()];
			AD[0] = depth;
			builder.AD(AD);
		}

		if (createRefGTs) {
			final int ploidy = oldGT.getPloidy();
			final List<Allele> refAlleles = Collections.nCopies(ploidy, VC.getReference());

			// keep 0 depth samples and 0 GQ samples as no-call
			if (depth > 0 && oldGT.hasGQ() && oldGT.getGQ() > 0) {
				builder.alleles(refAlleles);
			}

			// also, the PLs are technically no longer usable
			builder.noPL();
		}

		recoveredGs.add(builder.noAttributes().attributes(attrs).make());
	}
	return recoveredGs;
}
 
开发者ID:BGI-flexlab,项目名称:SOAPgaea,代码行数:55,代码来源:JointCallingEngine.java


注:本文中的htsjdk.variant.variantcontext.Genotype.getExtendedAttributes方法示例由纯净天空整理自Github/MSDocs等开源代码及文档管理平台,相关代码片段筛选自各路编程大神贡献的开源项目,源码版权归原作者所有,传播和使用请参考对应项目的License;未经允许,请勿转载。